AKT1S1
Gene Ontology Biological Process
Gene Ontology Cellular Component
AKT2
Gene Ontology Biological Process
- activation of Ral GTPase activity [IGI]
- cellular response to insulin stimulus [IDA, ISO]
- cellular response to organic cyclic compound [ISO]
- insulin receptor signaling pathway [IDA, ISO]
- intracellular protein transmembrane transport [IMP]
- negative regulation of RNA splicing [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- peripheral nervous system myelin maintenance [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell motility [ISO]
- positive regulation of fatty acid beta-oxidation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose import in response to insulin stimulus [IGI]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of signal transduction [ISO]
- positive regulation of sodium ion transport [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vesicle fusion [IMP]
- protein kinase B signaling [ISO]
- protein localization to plasma membrane [IGI]
- protein phosphorylation [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.
The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity. One of the top cellular functions differentially regulated by Akt isoforms is RNA processing. IWS1, an RNA processing regulator, is phosphorylated by Akt3 and Akt1 at Ser720/Thr721. The latter is required for the recruitment ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID