BAIT
PPP1R9B
SPL, Spn, RP23-112C19.3
protein phosphatase 1, regulatory subunit 9B
GO Process (10)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- actin cytoskeleton organization [TAS]
- actin filament organization [IPI]
- calcium-mediated signaling [IMP]
- cell migration [ISO]
- cellular response to morphine [IMP]
- dendrite development [IMP]
- filopodium assembly [ISO]
- negative regulation of cell growth [ISO]
- regulation of opioid receptor signaling pathway [IMP]
- regulation of protein phosphorylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SYT1
AW124717, G630098F17Rik, SytI
synaptotagmin I
GO Process (9)
GO Function (15)
GO Component (13)
Gene Ontology Biological Process
- detection of calcium ion [ISO]
- neurotransmitter secretion [IDA]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of vesicle fusion [ISO]
- regulation of calcium ion-dependent exocytosis [ISO]
- regulation of regulated secretory pathway [ISO]
- response to calcium ion [ISO]
- synaptic vesicle exocytosis [IMP]
- vesicle docking [ISO]
Gene Ontology Molecular Function- SNARE binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [IPI, ISO]
- calmodulin binding [ISO]
- clathrin binding [ISO]
- identical protein binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [ISO]
- phospholipid binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [ISO]
- SNARE binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [IPI, ISO]
- calmodulin binding [ISO]
- clathrin binding [ISO]
- identical protein binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [ISO]
- phospholipid binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- cell [IMP]
- cytoplasm [ISO]
- dense core granule [ISO]
- excitatory synapse [ISO]
- intracellular organelle [ISO]
- neuron projection [IDA]
- plasma membrane [ISO, TAS]
- presynaptic membrane [IDA]
- secretory granule [IDA, ISO]
- synaptic vesicle [IDA, ISO, TAS]
- synaptic vesicle membrane [IDA]
- terminal bouton [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.
Glutamatergic projections from the cortex and dopaminergic projections from the substantia nigra or ventral tegmental area synapse on dendritic spines of specific GABAergic medium spiny neurons (MSNs) in the striatum. Direct pathway MSNs (dMSNs) are positively coupled to protein kinase A (PKA) signaling and activation of these neurons enhance specific motor programs whereas indirect pathway MSNs (iMSNs) are negatively coupled ... [more]
Proteomes Dec. 17, 2018; 6(4); [Pubmed: 30562941]
Throughput
- High Throughput
Curated By
- BioGRID