BAIT

FCGR2B

CD32, CD32B, FCG2, FCGR2, IGFR2, RP11-474I16.2

Fc fragment of IgG, low affinity IIb, receptor (CD32)

Alzheimer's Disease Project

GO Process (3)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

immune response [TAS]

regulation of immune response [TAS]

signal transduction [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

plasma membrane [TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

PTPN6

HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1

protein tyrosine phosphatase, non-receptor type 6

GO Process (22)

GO Function (4)

GO Component (6)

Gene Ontology Biological Process

G-protein coupled receptor signaling pathway [TAS]

JAK-STAT cascade involved in growth hormone signaling pathway [TAS]

T cell costimulation [TAS]

apoptotic process [TAS]

blood coagulation [TAS]

cell differentiation [IDA]

cell proliferation [IDA]

cytokine-mediated signaling pathway [TAS]

interferon-gamma-mediated signaling pathway [TAS]

leukocyte migration [TAS]

negative regulation of cell proliferation [NAS]

negative regulation of peptidyl-tyrosine phosphorylation [IMP]

peptidyl-tyrosine dephosphorylation [IDA, TAS]

peptidyl-tyrosine phosphorylation [IDA]

positive regulation of cell proliferation [IMP]

positive regulation of phosphatidylinositol 3-kinase signaling [IMP]

protein dephosphorylation [IDA]

regulation of ERK1 and ERK2 cascade [IDA]

regulation of G1/S transition of mitotic cell cycle [IMP]

regulation of interferon-gamma-mediated signaling pathway [TAS]

regulation of type I interferon-mediated signaling pathway [TAS]

type I interferon signaling pathway [TAS]

Gene Ontology Molecular Function

protein binding [IPI]
protein kinase binding [IPI]
protein tyrosine phosphatase activity [TAS]
transmembrane receptor protein tyrosine phosphatase activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

nucleolus [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.

Pei D, Wang J, Walsh CT

SH-PTP1 (also known as PTP1C, HCP, and SHP) is a non-transmembrane protein tyrosine phosphatase (PTPase) containing two tandem Src homology 2 (SH2) domains. We show here that the two SH2 (N-SH2 and C-SH2) domains in SH-PTP1 have different functions in regulation of the PTPase domain and thereby signal transduction. While the N-terminal SH2 domain is both necessary and sufficient for ... [more]

Proc. Natl. Acad. Sci. U.S.A. Feb. 06, 1996; 93(3);1141-5 [Pubmed: 8577729]

Throughput

Low Throughput

Curated By

BioGRID