AGAP2
Gene Ontology Biological Process
- mammary gland alveolus development [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of JAK-STAT cascade [ISO]
- positive regulation of mammary gland epithelial cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein kinase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
HOMER2
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA]
- behavioral response to cocaine [ISO]
- calcium-mediated signaling using intracellular calcium source [ISO]
- chemical homeostasis within a tissue [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of store-operated calcium entry [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.
Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demonstrate physiologic binding of PIKE-L to Homer, an adaptor protein known to link metabotropic glutamate ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID