MOG1
Gene Ontology Biological Process
Gene Ontology Molecular Function
SUS1
Gene Ontology Biological Process
- histone H3-K4 methylation [IMP]
- histone H3-K79 methylation [IMP]
- histone deubiquitination [IMP]
- nuclear retention of pre-mRNA at the site of transcription [IMP]
- poly(A)+ mRNA export from nucleus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, IPI]
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
- regulation of protein localization [IMP]
- transcription elongation from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A role for Mog1 in H2Bub1 and H3K4me3 regulation affecting RNAPII transcription and mRNA export.
Monoubiquitination of histone H2B (to H2Bub1) is required for downstream events including histone H3 methylation, transcription, and mRNA export. The mechanisms and players regulating these events have not yet been completely delineated. Here, we show that the conserved Ran-binding protein Mog1 is required to sustain normal levels of H2Bub1 and H3K4me3 in Saccharomyces cerevisiae Mog1 is needed for gene body ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUS1 MOG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.5305 | BioGRID | 358323 | |
| SUS1 MOG1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.6722 | BioGRID | 2081195 | |
| MOG1 SUS1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 2469346 |
Curated By
- BioGRID