BAIT
CEBPB
Il6dbp, NF-IL6, TCF5
CCAAT/enhancer binding protein (C/EBP), beta
GO Process (18)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- brown fat cell differentiation [ISO]
- cellular response to amino acid stimulus [ISO]
- embryonic placenta development [ISO]
- fat cell differentiation [ISO]
- mammary gland epithelial cell differentiation [ISO]
- mammary gland epithelial cell proliferation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neuron differentiation [ISO]
- positive regulation of fat cell differentiation [ISO, ISS]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of interleukin-6 biosynthetic process [ISO]
- regulation of transcription involved in cell fate commitment [ISO, ISS]
- regulation of transcription, DNA-templated [IC, ISO, ISS]
- response to endoplasmic reticulum stress [ISO, ISS]
- response to lipopolysaccharide [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO, ISS]
- chromatin binding [ISO]
- glucocorticoid receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI, ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- transcription factor binding [IPI]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO, ISS]
- chromatin binding [ISO]
- glucocorticoid receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI, ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PRPF19
AA617263, AL024362, D19Wsu55e, NMP200, PSO4, Prp19, Snev
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
GO Process (17)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- cellular protein localization [ISO]
- double-strand break repair via nonhomologous end joining [ISO]
- generation of catalytic spliceosome for first transesterification step [IBA]
- inner cell mass cell proliferation [IMP]
- lipid biosynthetic process [IDA]
- mRNA splicing, via spliceosome [ISO]
- negative regulation of neuron differentiation [IDA]
- positive regulation of astrocyte differentiation [IDA]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of neuron differentiation [ISA]
- proteasomal protein catabolic process [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IBA]
- signal transduction involved in DNA damage checkpoint [ISO]
- spliceosomal complex assembly [ISO]
- spliceosomal tri-snRNP complex assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- DNA replication factor A complex [ISO]
- Prp19 complex [IBA, ISO]
- U2-type catalytic step 1 spliceosome [IBA]
- catalytic step 2 spliceosome [IBA, ISO]
- cytoplasm [IDA, ISO]
- lipid particle [IDA]
- membrane [ISO]
- nuclear speck [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISA, ISO]
- site of double-strand break [ISO]
- spliceosomal complex [IDA, ISA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.
C/EBPa and C/EBPb are transcription factors with tissue specific expression regulating several important cellular processes. They work by recruiting protein complexes to a common DNA recognition motif and both are able to compensate each other's absence in many cell types, thus showing functional redundancy. They also play distinct roles in specific cellular pathways and their abnormal functioning gives raise to ... [more]
Biochim Biophys Acta Gen Subj Feb. 01, 2017; 1861(2);467-476 [Pubmed: 27746211]
Throughput
- High Throughput
Additional Notes
- Source of Cebpb not clear
Curated By
- BioGRID