MYH6
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- adult heart development [IMP]
- atrial cardiac muscle tissue morphogenesis [IMP]
- cardiac muscle fiber development [ISS]
- in utero embryonic development [ISS]
- muscle contraction [IDA]
- muscle filament sliding [IMP, TAS]
- myofibril assembly [ISS]
- regulation of ATPase activity [ISS]
- regulation of blood pressure [ISS]
- regulation of heart contraction [ISS]
- regulation of heart rate [IDA]
- regulation of the force of heart contraction [IDA, ISS]
- sarcomere organization [ISS]
- striated muscle contraction [IMP, ISS]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- visceral muscle development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CALCOCO1
Gene Ontology Biological Process
Gene Ontology Molecular Function- armadillo repeat domain binding [IPI]
- beta-catenin binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IMP, ISS]
- transcription cofactor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IMP, ISS]
- transcription cofactor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription.
Myosin VI (MVI) has been found to be overexpressed in ovarian, breast and prostate cancers. Moreover, it has been shown to play a role in regulating cell proliferation and migration, and to interact with RNA Polymerase II (RNAPII). Here, we find that backfolding of MVI regulates its ability to bind DNA and that a putative transcription co-activator NDP52 relieves the auto-inhibition of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID