BAIT

TXNIP

EST01027, HHCPA78, THIF, VDUP1, RP11-315I20.4
thioredoxin interacting protein
UPS Project
Homo sapiens
PREY

ATAD3A

RP5-832C2.1
ATPase family, AAA domain containing 3A
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.

Ohtake F, Tsuchiya H, Saeki Y, Tanaka K

Different polyubiquitin chain linkages direct substrates toward distinct cellular pathways. K63-linked ubiquitylation is known to regulate proteasome-independent events such as signal transduction, but its function in the context of heterogeneous ubiquitin chains remains unclear. Here, we report that K63 ubiquitylation plays a critical role in proteasome-mediated substrate degradation by serving as a "seed" for K48/K63 branched ubiquitin chains. Quantitative analysis ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 13, 2017; 115(7);E1401-E1408 [Pubmed: 29378950]

Throughput

  • High Throughput

Curated By

  • BioGRID