BAIT
APMAP
2310001A20Rik, AI314817, RP23-156P22.2
adipocyte plasma membrane associated protein
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RTN4
1110020G17Rik, AA407876, AA409940, AA960376, ASY, C130026I10Rik, NOGO, NSP-CL, NgA, Nogo-A, Nogo-B, Nogo-C, mKIAA0886, mKIAA4153, RP23-176O5.4
reticulon 4
GO Process (19)
GO Function (3)
GO Component (13)
Gene Ontology Biological Process
- angiogenesis [IMP]
- axonal fasciculation [IMP, ISO]
- cardiac epithelial to mesenchymal transition [IMP]
- cerebral cortex radial glia guided migration [IMP]
- endoplasmic reticulum tubular network organization [ISO]
- negative regulation of axon extension [IMP, ISO, ISS]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of neuron projection development [ISO]
- negative regulation of neuron projection regeneration [ISO]
- nervous system development [IDA]
- positive regulation of dopamine secretion [ISO]
- positive regulation of glial cell differentiation [ISO]
- regulation of axon regeneration [ISO]
- regulation of branching morphogenesis of a nerve [IMP, ISO]
- regulation of cell migration [ISO]
- regulation of nervous system development [IMP]
- regulation of sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell projection [IDA]
- cytoplasm [ISO]
- endoplasmic reticulum [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of endoplasmic reticulum membrane [ISO, ISS]
- intracellular [ISO]
- myelin sheath [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear envelope [ISO, ISS]
- plasma membrane [ISO]
- protein complex [ISO]
Mus musculus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer's disease (AD). In this study, behavioral investigations revealed spatial learning and memory deficiencies in our newly generated mouse line lacking the protein APMAP. In a mouse model ... [more]
Acta Neuropathol Commun Jan. 31, 2019; 7(1);13 [Pubmed: 30704515]
Throughput
- Low Throughput
Curated By
- BioGRID