BAIT
APMAP
2310001A20Rik, AI314817, RP23-156P22.2
adipocyte plasma membrane associated protein
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CANX
1110069N15Rik, AI988026, Cnx, D11Ertd153e, RP23-237P10.2
calnexin
GO Process (3)
GO Function (6)
GO Component (16)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER-mitochondrion membrane contact site [ISO]
- axon [ISO]
- cell [IMP]
- cytoplasm [ISO]
- dendrite cytoplasm [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- integral component of membrane [IDA]
- membrane [IDA, ISO]
- myelin sheath [IDA]
- neuronal cell body [ISO]
- protein complex [ISO]
- ribosome [ISO]
- rough endoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer's disease (AD). In this study, behavioral investigations revealed spatial learning and memory deficiencies in our newly generated mouse line lacking the protein APMAP. In a mouse model ... [more]
Acta Neuropathol Commun Jan. 31, 2019; 7(1);13 [Pubmed: 30704515]
Throughput
- Low Throughput
Curated By
- BioGRID