BAIT
APMAP
2310001A20Rik, AI314817, RP23-156P22.2
adipocyte plasma membrane associated protein
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LAMP1
AI196048, CD107a, Lamp-1
lysosomal-associated membrane protein 1
GO Process (9)
GO Function (3)
GO Component (21)
Gene Ontology Biological Process
- Golgi to lysosome transport [ISO]
- autophagic cell death [ISO]
- establishment of protein localization to organelle [ISO]
- granzyme-mediated apoptotic signaling pathway [ISO]
- positive regulation of natural killer cell degranulation [ISO]
- positive regulation of natural killer cell mediated cytotoxicity [ISO]
- protein stabilization [IMP]
- regulation of organelle transport along microtubule [ISO]
- spermatogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alveolar lamellar body [ISO]
- cell surface [IDA]
- cytolytic granule [IDA]
- cytoplasm [ISO]
- cytoplasmic vesicle [ISO]
- dendrite [ISO]
- endosome [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- late endosome [IDA, ISO]
- lysosome [IDA, ISO]
- melanosome [IDA]
- membrane [ISO]
- multivesicular body [IDA, ISO]
- neuronal cell body [ISO]
- phagolysosome membrane [IDA]
- plasma membrane [ISO]
- sarcolemma [IDA]
- synaptic vesicle [IDA]
- vacuole [ISO]
- vesicle [IDA]
Mus musculus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer's disease (AD). In this study, behavioral investigations revealed spatial learning and memory deficiencies in our newly generated mouse line lacking the protein APMAP. In a mouse model ... [more]
Acta Neuropathol Commun Jan. 31, 2019; 7(1);13 [Pubmed: 30704515]
Throughput
- Low Throughput
Curated By
- BioGRID