BAIT
APMAP
2310001A20Rik, AI314817, RP23-156P22.2
adipocyte plasma membrane associated protein
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SFN
Er, Mme1, Ywhas, RP23-137L22.11-001
stratifin
GO Process (15)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- establishment of skin barrier [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- keratinization [IMP]
- keratinocyte development [IGI]
- keratinocyte differentiation [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of keratinocyte proliferation [IGI]
- positive regulation of cell growth [IDA]
- positive regulation of epidermal cell differentiation [IMP]
- positive regulation of protein export from nucleus [IDA]
- regulation of cell cycle [IDA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- regulation of epidermal cell division [IMP]
- release of cytochrome c from mitochondria [ISO]
- skin development [IGI, IMP]
Gene Ontology Molecular Function
Mus musculus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer's disease (AD). In this study, behavioral investigations revealed spatial learning and memory deficiencies in our newly generated mouse line lacking the protein APMAP. In a mouse model ... [more]
Acta Neuropathol Commun Jan. 31, 2019; 7(1);13 [Pubmed: 30704515]
Throughput
- Low Throughput
Curated By
- BioGRID