BAIT
MB21D1
C6orf150, cGAS, h-cGAS, RP11-398K22.2
Mab-21 domain containing 1
GO Process (6)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
VPS4A
SKD1, SKD1A, SKD2, VPS4, VPS4-1
vacuolar protein sorting 4 homolog A (S. cerevisiae)
GO Process (16)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [NAS]
- abscission [IMP]
- cytokinesis [IDA]
- cytokinesis checkpoint [IMP]
- cytoplasmic microtubule organization [IBA]
- endosomal transport [IMP, TAS]
- membrane organization [TAS]
- negative regulation of cytokinesis [IMP]
- positive regulation of exosomal secretion [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]
- vacuole organization [IBA]
- vesicle-mediated transport [IDA]
- viral budding via host ESCRT complex [IGI]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.
Viral DNA sensing is an essential component of the mammalian innate immune response. Upon binding viral DNA, the cyclic-GMP-AMP synthase (cGAS) catalyzes the production of cyclic dinucleotides to induce type I interferons. However, little is known about how cGAS is homeostatically maintained or regulated upon infection. Here, we define cytoplasmic cGAS interactions with cellular and viral proteins upon herpes simplex virus ... [more]
Cell Syst Dec. 26, 2018; 7(6);627-642.e6 [Pubmed: 30471916]
Throughput
- High Throughput
Curated By
- BioGRID