IL1RAPL1
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- negative regulation of exocytosis [IDA]
- neuron differentiation [ISS]
- positive regulation of dendrite morphogenesis [ISS]
- presynaptic membrane assembly [ISS]
- regulation of neuron projection development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPRD
Gene Ontology Biological Process
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- neuron differentiation [ISS]
- peptidyl-tyrosine dephosphorylation [TAS]
- phosphate-containing compound metabolic process [NAS]
- positive regulation of dendrite morphogenesis [ISS]
- presynaptic membrane assembly [ISS]
- protein dephosphorylation [TAS]
- transmembrane receptor protein tyrosine phosphatase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.
Mutations of the Interleukin-1-receptor accessory protein like 1 (IL1RAPL1) gene are associated with cognitive impairment ranging from non-syndromic X-linked mental retardation to autism. IL1RAPL1 belongs to a novel family of IL1/Toll receptors, which is localized at excitatory synapses and interacts with PSD-95. We previously showed that IL1RAPL1 regulates the synaptic localization of PSD-95 by controlling c-Jun N-terminal kinase activity and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID