ARHGAP22
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IL1RAPL1
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- negative regulation of exocytosis [IDA]
- neuron differentiation [ISS]
- positive regulation of dendrite morphogenesis [ISS]
- presynaptic membrane assembly [ISS]
- regulation of neuron projection development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2.
Mutations of the Interleukin-1-receptor accessory protein like 1 (IL1RAPL1) gene are associated with cognitive impairment ranging from non-syndromic X-linked mental retardation to autism. IL1RAPL1 belongs to a novel family of IL1/Toll receptors, which is localized at excitatory synapses and interacts with PSD-95. We previously showed that IL1RAPL1 regulates the synaptic localization of PSD-95 by controlling c-Jun N-terminal kinase activity and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IL1RAPL1 ARHGAP22 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| IL1RAPL1 ARHGAP22 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID