BAIT
SDC2
CD362, HSPG, HSPG1, SYND2
syndecan 2
GO Process (10)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- phototransduction, visible light [TAS]
- regulation of dendrite morphogenesis [ISS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGB4
CD104
integrin, beta 4
GO Process (14)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- amelogenesis [IMP]
- autophagy [IMP]
- cell adhesion [NAS]
- cell junction assembly [TAS]
- cell motility [IMP]
- cell-matrix adhesion [IMP]
- digestive tract development [IMP]
- extracellular matrix organization [TAS]
- hemidesmosome assembly [IDA, IMP, TAS]
- mesodermal cell differentiation [IEP]
- nail development [IMP]
- renal system development [IMP]
- response to wounding [IDA]
- skin development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation.
The alpha6beta4 integrin is a laminin 332 (LN332) receptor central to the formation of hemidesmosomes in epithelial layers. However, the integrin becomes phosphorylated by keratinocytes responding to epidermal growth factor in skin wounds or by squamous cell carcinomas that overexpress/hyperactivate the tyrosine kinase ErbB2, epidermal growth factor receptor, or c-Met. We show here that the beta4-dependent signaling in A431 human ... [more]
J. Biol. Chem. Apr. 30, 2010; 285(18);13569-79 [Pubmed: 20181947]
Throughput
- Low Throughput
Curated By
- BioGRID