CAV3
Gene Ontology Biological Process
- T-tubule organization [TAS]
- caveola assembly [IDA]
- cell differentiation [ISS]
- cell growth [ISS]
- cholesterol homeostasis [ISS]
- endocytosis [ISS]
- glucose homeostasis [ISS]
- membrane raft organization [ISS]
- muscle cell cellular homeostasis [ISS]
- muscle organ development [TAS]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [ISS]
- negative regulation of calcium ion transport [IDA]
- negative regulation of cardiac muscle hypertrophy [IMP]
- negative regulation of cell size [IMP]
- negative regulation of nitric-oxide synthase activity [ISS]
- negative regulation of potassium ion transmembrane transport [ISS]
- negative regulation of potassium ion transmembrane transporter activity [ISS]
- negative regulation of protein kinase activity [ISS]
- negative regulation of protein localization to cell surface [NAS]
- negative regulation of sarcomere organization [IMP]
- plasma membrane organization [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of microtubule polymerization [ISS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [NAS]
- protein localization [ISS]
- protein localization to plasma membrane [ISS]
- regulation of calcium ion import [IDA]
- regulation of calcium ion transmembrane transporter activity [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of heart contraction [ISS]
- regulation of heart rate [IMP]
- regulation of membrane depolarization during cardiac muscle cell action potential [IMP]
- regulation of membrane potential [IDA]
- regulation of nerve growth factor receptor activity [IMP]
- regulation of signal transduction by receptor internalization [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of ventricular cardiac muscle cell membrane depolarization [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- triglyceride metabolic process [ISS]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RYR1
Gene Ontology Biological Process
- calcium ion transport [ISS]
- cellular response to caffeine [ISS]
- cytosolic calcium ion homeostasis [ISS]
- ion transmembrane transport [TAS]
- muscle contraction [ISS]
- ossification involved in bone maturation [ISS]
- outflow tract morphogenesis [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- response to caffeine [ISS]
- response to hypoxia [IDA]
- skeletal muscle fiber development [ISS]
- skin development [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Characterization of the molecular architecture of human caveolin-3 and interaction with the skeletal muscle ryanodine receptor.
Caveolin-3 facilitates both caveolae formation and a range of cell signaling pathways, including Ca(2+) homeostasis.Caveolin-3 forms a disc-shaped nonamer that binds the Ca(2+)-release channel, RyR1.Multiple caveolin-3 nonamers bind to a single RyR1 homotetramer.First three-dimensional structural insights into caveolin-3 assembly, interactions with RyR1 suggest a novel role in muscle contraction and/or for channel localization within the membrane. Caveolin-3 (cav-3), an integral ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID