BAIT
GLP1R
glucagon-like peptide 1 receptor
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAO1
AW050213, Galphao, Gnao, alphaO
guanine nucleotide binding protein, alpha O
GO Process (11)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP, ISO, TAS]
- GTP catabolic process [ISO]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- aging [ISO]
- cellular process [IMP]
- dopamine receptor signaling pathway [IMP]
- locomotory behavior [IMP]
- negative regulation of calcium ion transport [ISO]
- positive regulation of GTPase activity [ISO]
- regulation of heart contraction [IMP]
- response to organonitrogen compound [ISO]
Gene Ontology Molecular Function- G-protein beta/gamma-subunit complex binding [IBA]
- G-protein coupled serotonin receptor binding [IBA, ISO]
- GTP binding [IMP, ISO]
- GTPase activating protein binding [ISO]
- GTPase activity [IDA, ISO, TAS]
- corticotropin-releasing hormone receptor 1 binding [IBA, ISO]
- mu-type opioid receptor binding [IBA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- signal transducer activity [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- G-protein coupled serotonin receptor binding [IBA, ISO]
- GTP binding [IMP, ISO]
- GTPase activating protein binding [ISO]
- GTPase activity [IDA, ISO, TAS]
- corticotropin-releasing hormone receptor 1 binding [IBA, ISO]
- mu-type opioid receptor binding [IBA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- signal transducer activity [IBA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from pancreatic β cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2 diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-1, affinity purification and mass spectrometry (AP-MS) were employed to ... [more]
Mol. Cell Proteomics Nov. 01, 2014; 13(11);3049-62 [Pubmed: 25044020]
Throughput
- High Throughput
Curated By
- BioGRID