BAIT
GLP1R
glucagon-like peptide 1 receptor
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAI2
C76432, Galphai2, Gia, Gnai-2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
GO Process (14)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IMP]
- G-protein coupled receptor signaling pathway [ISO]
- GTP catabolic process [IBA]
- activation of MAPKK activity [ISO]
- adenosine receptor signaling pathway [IBA, ISO]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IMP, ISA]
- cell division [ISO]
- cell proliferation [IPI]
- gamma-aminobutyric acid signaling pathway [IBA, ISO]
- intracellular signal transduction [ISO]
- negative regulation of synaptic transmission [ISO]
- positive regulation of cell proliferation [ISO]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from pancreatic β cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2 diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-1, affinity purification and mass spectrometry (AP-MS) were employed to ... [more]
Mol. Cell Proteomics Nov. 01, 2014; 13(11);3049-62 [Pubmed: 25044020]
Throughput
- High Throughput
Curated By
- BioGRID