BAIT
GLP1R
glucagon-like peptide 1 receptor
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAP1A
AI848598, G-22K, Krev-1, Rap1
RAS-related protein-1a
GO Process (15)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- Rap protein signal transduction [ISO]
- cellular response to cAMP [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- establishment of endothelial barrier [ISO]
- negative regulation of synaptic vesicle exocytosis [IGI]
- nerve growth factor signaling pathway [ISO]
- positive regulation of ERK1 and ERK2 cascade [IGI, ISO]
- positive regulation of Rap GTPase activity [ISO]
- positive regulation of neuron projection development [IDA, ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of vasculogenesis [IMP]
- protein transport [ISO]
- regulation of cell junction assembly [ISO]
- small GTPase mediated signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from pancreatic β cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2 diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-1, affinity purification and mass spectrometry (AP-MS) were employed to ... [more]
Mol. Cell Proteomics Nov. 01, 2014; 13(11);3049-62 [Pubmed: 25044020]
Throughput
- High Throughput
Curated By
- BioGRID