BAIT

GLP1R

glucagon-like peptide 1 receptor

Alzheimer's Disease Project

Synthetic Protein Interaction Project

GO Process (6)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

activation of adenylate cyclase activity [TAS]

cAMP-mediated signaling [IDA]

energy reserve metabolic process [TAS]

positive regulation of cytosolic calcium ion concentration [IDA]

regulation of insulin secretion [TAS]

small molecule metabolic process [TAS]

Gene Ontology Molecular Function

transmembrane signaling receptor activity [TAS]

Gene Ontology Cellular Component

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ATP1B1

Atp4b, Atpb, Atpb-1, NKbeta1

ATPase, Na+/K+ transporting, beta 1 polypeptide

GO Process (26)

GO Function (5)

GO Component (11)

Gene Ontology Biological Process

ATP catabolic process [ISO]

blastocyst development [IMP]

cardiac muscle contraction [IMP]

cellular calcium ion homeostasis [IMP]

cellular potassium ion homeostasis [ISO]

cellular sodium ion homeostasis [ISO]

membrane repolarization [ISO]

metal ion transport [ISO]

positive regulation of ATP catabolic process [ISO]

positive regulation of ATPase activity [ISO]

positive regulation of calcium:sodium antiporter activity [IMP]

positive regulation of potassium ion import [ISO]

positive regulation of potassium ion transmembrane transporter activity [ISO]

positive regulation of sodium ion export from cell [ISO]

potassium ion import [IC, ISO]

potassium ion transport [ISO]

protein localization to plasma membrane [ISO]

protein stabilization [IMP, ISO]

regulation of calcium ion transmembrane transport [IMP]

regulation of cardiac muscle contraction by calcium ion signaling [IMP]

regulation of gene expression [IMP]

relaxation of cardiac muscle [IMP]

response to hypoxia [ISO]

sodium ion export from cell [IC, ISO]

sodium ion transmembrane transport [ISO]

sodium ion transport [ISO]

Gene Ontology Molecular Function

ATPase activator activity [ISO]
ATPase binding [ISO]
MHC class II protein complex binding [ISO]
protein binding [IPI]
sodium:potassium-exchanging ATPase activity [IMP, ISO]

Gene Ontology Cellular Component

apical plasma membrane [IDA, ISO]

basolateral plasma membrane [IDA, ISO]

extracellular vesicular exosome [ISO]

intercalated disc [IMP]

intracellular [IMP]

myelin sheath [IDA]

plasma membrane [IDA, ISO]

sarcolemma [IMP]

sodium:potassium-exchanging ATPase complex [IMP, ISO]

CRISPR Database MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic Î² cells.

Zhang M, Robitaille M, Showalter AD, Huang X, Liu Y, Bhattacharjee A, Willard FS, Han J, Froese S, Wei L, Gaisano HY, Angers S, Sloop KW, Dai FF, Wheeler MB

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from pancreatic Î² cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2 diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-1, affinity purification and mass spectrometry (AP-MS) were employed to ... [more]

Mol. Cell Proteomics Nov. 01, 2014; 13(11);3049-62 [Pubmed: 25044020]

Throughput

High Throughput

Curated By

BioGRID