BAIT

GLP1R

glucagon-like peptide 1 receptor

Alzheimer's Disease Project

Synthetic Protein Interaction Project

GO Process (6)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

activation of adenylate cyclase activity [TAS]

cAMP-mediated signaling [IDA]

energy reserve metabolic process [TAS]

positive regulation of cytosolic calcium ion concentration [IDA]

regulation of insulin secretion [TAS]

small molecule metabolic process [TAS]

Gene Ontology Molecular Function

transmembrane signaling receptor activity [TAS]

Gene Ontology Cellular Component

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

ARF1

RP23-192P17.1

ADP-ribosylation factor 1

GO Process (18)

GO Function (6)

GO Component (9)

Gene Ontology Biological Process

Golgi to transport vesicle transport [ISO]

actin filament organization [ISO]

cellular copper ion homeostasis [ISO]

dendritic spine organization [ISO]

long term synaptic depression [ISO]

positive regulation of ER to Golgi vesicle-mediated transport [ISO]

positive regulation of calcium ion-dependent exocytosis [ISO]

positive regulation of dendritic spine development [ISO]

positive regulation of endocytosis [ISO]

positive regulation of late endosome to lysosome transport [ISO]

positive regulation of protein secretion [ISO]

positive regulation of sodium ion transmembrane transport [ISO]

protein transport [TAS]

regulation of Arp2/3 complex-mediated actin nucleation [ISO]

regulation of receptor internalization [ISO]

synaptic vesicle budding [ISO]

very-low-density lipoprotein particle assembly [ISO]

vesicle-mediated transport [IDA]

Gene Ontology Molecular Function

GDP binding [ISO]
GTP binding [ISO, TAS]
magnesium ion binding [ISO]
poly(A) RNA binding [ISO]
protein binding [IPI]
protein homodimerization activity [ISO]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

cytosol [IDA, ISO]

endomembrane system [IDA]

extracellular vesicular exosome [ISO]

focal adhesion [ISO]

late endosome [ISO]

sarcomere [IDA]

trans-Golgi network [ISO]

CRISPR Database MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic Î² cells.

Zhang M, Robitaille M, Showalter AD, Huang X, Liu Y, Bhattacharjee A, Willard FS, Han J, Froese S, Wei L, Gaisano HY, Angers S, Sloop KW, Dai FF, Wheeler MB

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from pancreatic Î² cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2 diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-1, affinity purification and mass spectrometry (AP-MS) were employed to ... [more]

Mol. Cell Proteomics Nov. 01, 2014; 13(11);3049-62 [Pubmed: 25044020]

Throughput

High Throughput

Curated By

BioGRID