BAIT
GLP1R
glucagon-like peptide 1 receptor
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VAPA
33kDa, VAP33
vesicle-associated membrane protein, associated protein A
GO Process (10)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- COPII-coated vesicle budding [ISO]
- ER to Golgi vesicle-mediated transport [ISO]
- cell death [ISO]
- negative regulation by host of viral genome replication [ISO]
- neuron projection development [ISO]
- positive regulation by host of viral genome replication [ISO]
- positive regulation by host of viral release from host cell [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- protein localization to endoplasmic reticulum [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from pancreatic β cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2 diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-1, affinity purification and mass spectrometry (AP-MS) were employed to ... [more]
Mol. Cell Proteomics Nov. 01, 2014; 13(11);3049-62 [Pubmed: 25044020]
Throughput
- High Throughput
Curated By
- BioGRID