BAIT
GLP1R
glucagon-like peptide 1 receptor
GO Process (6)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB5A
2410015H04Rik, AI663973, AU021172, nnyRab5a
RAB5A, member RAS oncogene family
GO Process (16)
GO Function (6)
GO Component (26)
Gene Ontology Biological Process
- GTP catabolic process [IDA, ISO]
- Rab protein signal transduction [IBA]
- early endosome to late endosome transport [ISO]
- endocytosis [IDA, ISO]
- endosome organization [ISO]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- receptor internalization involved in canonical Wnt signaling pathway [ISO]
- regulation of endocytosis [IBA]
- regulation of endosome size [ISO]
- regulation of filopodium assembly [IBA, ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic vesicle exocytosis [ISO]
- synaptic vesicle recycling [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [ISO]
- axon terminus [ISO]
- cell [IBA]
- cytoplasm [IDA, ISO]
- cytoplasmic side of early endosome membrane [ISO]
- cytosol [ISO]
- dendrite [ISO]
- early endosome [IDA, ISO]
- endocytic vesicle [IDA]
- endosome [IDA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- membrane raft [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- phagocytic vesicle [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- recycling endosome [ISO]
- ruffle [IDA]
- somatodendritic compartment [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- zymogen granule membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from pancreatic β cells, GLP-1 receptor (GLP-1R) agonists are now important therapeutic options for the treatment of type 2 diabetes. To better understand the mechanisms that control the insulinotropic actions of GLP-1, affinity purification and mass spectrometry (AP-MS) were employed to ... [more]
Mol. Cell Proteomics Nov. 01, 2014; 13(11);3049-62 [Pubmed: 25044020]
Throughput
- High Throughput
Curated By
- BioGRID