PLXNB1
Gene Ontology Biological Process
- axon guidance [TAS]
- cell migration [NAS]
- intracellular signal transduction [NAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast proliferation [ISS]
- neuron projection morphogenesis [ISS]
- ossification involved in bone maturation [ISS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- regulation of cell shape [IDA]
- regulation of cytoskeleton organization [IDA]
- semaphorin-plexin signaling pathway [IDA]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLXNB1
Gene Ontology Biological Process
- axon guidance [TAS]
- cell migration [NAS]
- intracellular signal transduction [NAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast proliferation [ISS]
- neuron projection morphogenesis [ISS]
- ossification involved in bone maturation [ISS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- regulation of cell shape [IDA]
- regulation of cytoskeleton organization [IDA]
- semaphorin-plexin signaling pathway [IDA]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.
Signaling in eukaryotic cells frequently relies on dynamic interactions of single-pass membrane receptors involving their transmembrane (TM) domains. To search for new such interactions, we have developed a bacterial two-hybrid system to screen for both homotypic and heterotypic interactions between TM helices. We have explored the dimerization of TM domains from 16 proteins involved in both receptor tyrosine kinase and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLXNB1 PLXNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID