BAIT
NRP2
NP2, NPN2, PRO2714, VEGF165R2
neuropilin 2
GO Process (12)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- angiogenesis [NAS]
- axon extension involved in axon guidance [ISS]
- axon guidance [NAS, TAS]
- cell adhesion [NAS]
- nerve development [ISS]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of endothelial cell proliferation [TAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- sympathetic ganglion development [ISS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
- vascular endothelial growth factor receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
L1CAM
CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1
L1 cell adhesion molecule
GO Process (6)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.
Signaling in eukaryotic cells frequently relies on dynamic interactions of single-pass membrane receptors involving their transmembrane (TM) domains. To search for new such interactions, we have developed a bacterial two-hybrid system to screen for both homotypic and heterotypic interactions between TM helices. We have explored the dimerization of TM domains from 16 proteins involved in both receptor tyrosine kinase and ... [more]
J. Mol. Biol. Dec. 12, 2014; 426(24);4099-4111 [Pubmed: 25315821]
Throughput
- Low Throughput
Curated By
- BioGRID