PTPN1
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO, ISS]
- endoplasmic reticulum unfolded protein response [ISO, ISS]
- insulin receptor signaling pathway [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- peptidyl-tyrosine dephosphorylation [ISO]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [ISO]
- platelet-derived growth factor receptor-beta signaling pathway [ISO]
- protein dephosphorylation [IDA, IMP, ISO]
- regulation of endocytosis [ISO, ISS]
- regulation of hepatocyte growth factor receptor signaling pathway [ISO]
- regulation of insulin receptor signaling pathway [IMP]
- regulation of signal transduction [ISO, ISS]
Gene Ontology Molecular Function- enzyme binding [ISO]
- ephrin receptor binding [ISO]
- insulin receptor binding [IDA, IMP]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [IPI]
- protein tyrosine phosphatase activity [IDA, IMP, ISO]
- receptor tyrosine kinase binding [ISO]
- zinc ion binding [ISO]
- enzyme binding [ISO]
- ephrin receptor binding [ISO]
- insulin receptor binding [IDA, IMP]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [IPI]
- protein tyrosine phosphatase activity [IDA, IMP, ISO]
- receptor tyrosine kinase binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
SDCBP
Gene Ontology Biological Process
- actin cytoskeleton organization [NAS]
- axon guidance [TAS]
- intracellular signal transduction [NAS]
- positive regulation of JNK cascade [IC]
- positive regulation of exosomal secretion [IMP]
- positive regulation of extracellular vesicular exosome assembly [IMP]
- positive regulation of phosphorylation [IDA]
- protein targeting to membrane [NAS]
- substrate-dependent cell migration, cell extension [NAS]
- synaptic transmission [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin.
The tyrosine phosphatase r-PTPeta is able to suppress the malignant phenotype of rat thyroid tumorigenic cell lines. To identify r-PTPeta interacting proteins, a yeast two-hybrid screening was performed and an insert corresponding to the full-length syntenin cDNA was isolated. It encodes a protein containing two PDZ domains that mediates the binding of syntenin to proteins such as syndecan, proTGF-alpha, beta-ephrins ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPN1 SDCBP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID