BAIT
GPC1
glypican
glypican 1
GO Process (14)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- Schwann cell differentiation [ISS]
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- heparan sulfate proteoglycan catabolic process [IDA]
- myelin assembly [ISS]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISS]
- phototransduction, visible light [TAS]
- positive regulation of skeletal muscle cell differentiation [ISS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGB4
CD104
integrin, beta 4
GO Process (14)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- amelogenesis [IMP]
- autophagy [IMP]
- cell adhesion [NAS]
- cell junction assembly [TAS]
- cell motility [IMP]
- cell-matrix adhesion [IMP]
- digestive tract development [IMP]
- extracellular matrix organization [TAS]
- hemidesmosome assembly [IDA, IMP, TAS]
- mesodermal cell differentiation [IEP]
- nail development [IMP]
- renal system development [IMP]
- response to wounding [IDA]
- skin development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate.
ADAM17 (a disintegrin and metalloproteinase 17) is a plasma membrane metalloprotease involved in proteolytic release of the extracellular domain of many cell surface molecules, a process known as ectodomain shedding. Through this process, ADAM17 is implicated in several aspects of tumor growth and metastasis in a broad range of tumors, including head and neck squamous cell carcinomas (HNSCC). In this ... [more]
J Proteomics Dec. 16, 2016; 151();53-65 [Pubmed: 27576135]
Throughput
- High Throughput
Curated By
- BioGRID