BAIT
GPC1
glypican
glypican 1
GO Process (14)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- Schwann cell differentiation [ISS]
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- heparan sulfate proteoglycan catabolic process [IDA]
- myelin assembly [ISS]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISS]
- phototransduction, visible light [TAS]
- positive regulation of skeletal muscle cell differentiation [ISS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDGFA
PDGF-A, PDGF1
platelet-derived growth factor alpha polypeptide
GO Process (44)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- actin cytoskeleton organization [ISS]
- angiogenesis [ISS]
- blood coagulation [TAS]
- cell activation [TAS]
- cell projection assembly [ISS]
- cell-cell signaling [TAS]
- embryonic lung development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hair follicle development [ISS]
- innate immune response [TAS]
- lung alveolus development [ISS]
- negative chemotaxis [IDA]
- negative regulation of phosphatidylinositol biosynthetic process [IDA]
- negative regulation of platelet activation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- regulation of DNA biosynthetic process [IDA]
- regulation of actin cytoskeleton organization [TAS]
- regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling [ISS]
- regulation of glomerular mesangial cell proliferation [IDA]
- regulation of peptidyl-tyrosine phosphorylation [ISS]
- regulation of smooth muscle cell migration [IDA]
- response to wounding [IDA]
- skin development [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate.
ADAM17 (a disintegrin and metalloproteinase 17) is a plasma membrane metalloprotease involved in proteolytic release of the extracellular domain of many cell surface molecules, a process known as ectodomain shedding. Through this process, ADAM17 is implicated in several aspects of tumor growth and metastasis in a broad range of tumors, including head and neck squamous cell carcinomas (HNSCC). In this ... [more]
J Proteomics Dec. 16, 2016; 151();53-65 [Pubmed: 27576135]
Throughput
- High Throughput
Curated By
- BioGRID