BAIT
GPC1
glypican
glypican 1
GO Process (14)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- Schwann cell differentiation [ISS]
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- heparan sulfate proteoglycan catabolic process [IDA]
- myelin assembly [ISS]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISS]
- phototransduction, visible light [TAS]
- positive regulation of skeletal muscle cell differentiation [ISS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RACGAP1
CYK4, HsCYK-4, ID-GAP, MgcRacGAP
Rac GTPase activating protein 1
GO Process (16)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- actomyosin contractile ring assembly [IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- blood coagulation [TAS]
- cytokinesis, initiation of separation [IMP]
- embryo development [ISS]
- microtubule-based movement [TAS]
- mitotic cytokinesis [IDA, IMP]
- mitotic spindle midzone assembly [IDA]
- neuroblast proliferation [ISS]
- positive regulation of GTPase activity [IDA, IMP]
- positive regulation of cytokinesis [IDA, IMP]
- regulation of attachment of spindle microtubules to kinetochore [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- spermatogenesis [IEP]
- sulfate transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate.
ADAM17 (a disintegrin and metalloproteinase 17) is a plasma membrane metalloprotease involved in proteolytic release of the extracellular domain of many cell surface molecules, a process known as ectodomain shedding. Through this process, ADAM17 is implicated in several aspects of tumor growth and metastasis in a broad range of tumors, including head and neck squamous cell carcinomas (HNSCC). In this ... [more]
J Proteomics Dec. 16, 2016; 151();53-65 [Pubmed: 27576135]
Throughput
- High Throughput
Curated By
- BioGRID