NRXN1
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [IMP]
- angiogenesis [ISS]
- axon guidance [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cerebellar granule cell differentiation [ISS]
- establishment of protein localization [ISS]
- extracellular matrix organization [TAS]
- gamma-aminobutyric acid receptor clustering [ISS]
- gephyrin clustering [ISS]
- guanylate kinase-associated protein clustering [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- learning [IMP]
- negative regulation of filopodium assembly [ISS]
- neuroligin clustering [ISS]
- neuromuscular process controlling balance [IMP, ISS]
- neuron cell-cell adhesion [ISS, TAS]
- neuronal signal transduction [TAS]
- neurotransmitter secretion [ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synapse maturation [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein complex assembly involved in synapse maturation [ISS]
- protein localization to synapse [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse assembly [ISS]
- synaptic transmission [ISS]
- synaptic vesicle clustering [ISS]
- vocal learning [IMP]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NLGN1
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cytoskeletal matrix organization at active zone [ISS]
- establishment of protein localization [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- metabolic process [IBA]
- nervous system development [ISS]
- neurexin clustering [ISS]
- neuron cell-cell adhesion [ISS, TAS]
- neuronal signal transduction [TAS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of intracellular signal transduction [ISS]
- positive regulation of ruffle assembly [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- positive regulation of synaptic vesicle endocytosis [ISS]
- positive regulation of synaptic vesicle exocytosis [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein homooligomerization [ISS]
- protein localization to synapse [ISS]
- protein targeting [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of neuron differentiation [ISS]
- regulation of synaptic transmission [IBA]
- synapse assembly [IBA, ISS]
- synaptic vesicle clustering [ISS]
- synaptic vesicle targeting [ISS]
- terminal button organization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.
Neuroligins, proteins of the alpha/beta-hydrolase fold family, are found as postsynaptic transmembrane proteins whose extracellular domain associates with presynaptic partners, proteins of the neurexin family. To characterize the molecular basis of neuroligin interaction with neurexin-beta, we expressed five soluble and exportable forms of neuroligin-1 from recombinant DNA sources, by truncating the protein before the transmembrane span near its carboxyl terminus. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NRXN1 NLGN1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 2768646 | |
| NRXN1 NLGN1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID