NTRK2
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- brain-derived neurotrophic factor receptor signaling pathway [IMP]
- central nervous system neuron development [ISS]
- cerebral cortex development [ISS]
- learning [ISS]
- negative regulation of neuron apoptotic process [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of MAPK cascade [ISS]
- positive regulation of axonogenesis [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- protein autophosphorylation [ISS]
- regulation of Rac GTPase activity [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SOCS2
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- cellular response to hormone stimulus [IDA]
- cytokine-mediated signaling pathway [IBA]
- growth hormone receptor signaling pathway [IDA]
- negative regulation of JAK-STAT cascade [IBA]
- negative regulation of apoptotic process [TAS]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of protein kinase activity [IBA]
- positive regulation of signal transduction [TAS]
- regulation of cell growth [NAS]
- regulation of signal transduction [NAS]
- response to estradiol [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tropomyosin-Related Kinase B (TrkB) Regulates Neurite Outgrowth via a Novel Interaction with Suppressor of Cytokine Signalling 2 (SOCS2).
Brain-derived neurotrophic factor (BDNF) is highly expressed in the hippocampus, where it can initiate signalling pathways leading to neurite outgrowth, neuron survival, spine maturation and increased synapse strength. Although suppressor of cytokine signalling 2 (SOCS2) is primarily known to negatively regulate cytokine signalling, it is also highly expressed in the hippocampus and exerts neuron-specific functions in the brain, effecting the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOCS2 NTRK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID