BAIT
KDM6B
JMJD3
lysine (K)-specific demethylase 6B
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [ISS]
Homo sapiens
PREY
CORO1A
CLABP, CLIPINA, HCORO1, IMD8, TACO, p57
coronin, actin binding protein, 1A
GO Process (11)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- cell-substrate adhesion [IMP]
- cellular component movement [NAS]
- innate immune response [NAS]
- leukocyte chemotaxis [IBA]
- negative regulation of actin nucleation [IDA]
- phagocytosis [IMP]
- phagolysosome assembly [IMP]
- positive chemotaxis [IDA]
- regulation of cell shape [IBA]
- uropod organization [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy treatments show high response rates but have debilitating effects and carry risk of relapse. Previous work implicated NOTCH1 and other oncogenes. However, direct inhibition of these pathways affects healthy tissues and cancer alike. Our goal in this work has been to identify enzymes active in T-ALL ... [more]
Clin. Cancer Res. Jan. 01, 2019; 25(1);222-239 [Pubmed: 30224337]
Throughput
- High Throughput
Curated By
- BioGRID