BAIT
STAT3
ADMIO, APRF, HIES
signal transducer and activator of transcription 3 (acute-phase response factor)
GO Process (27)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISS, TAS]
- astrocyte differentiation [ISS]
- cellular component movement [TAS]
- cellular response to hormone stimulus [IDA]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [ISS]
- eye photoreceptor cell differentiation [ISS]
- glucose homeostasis [ISS]
- growth hormone receptor signaling pathway [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [ISS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein import into nucleus [IDA]
- radial glial cell differentiation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [IDA]
- sexual reproduction [ISS]
- signal transduction [TAS]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
PREY
TWIST1
ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, TWIST, bHLHa38
twist family bHLH transcription factor 1
GO Process (30)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- aortic valve morphogenesis [IMP]
- cell proliferation involved in heart valve development [IMP]
- cellular response to hypoxia [IMP]
- cranial suture morphogenesis [TAS]
- embryonic camera-type eye formation [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digit morphogenesis [TAS]
- eyelid development in camera-type eye [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- negative regulation of cellular senescence [IMP]
- negative regulation of double-strand break repair [IMP]
- negative regulation of histone phosphorylation [IMP]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of phosphatidylinositol 3-kinase signaling [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- ossification [TAS]
- outer ear morphogenesis [TAS]
- positive regulation of angiogenesis [NAS]
- positive regulation of cell motility [IMP, NAS]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of fatty acid beta-oxidation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-6 secretion [IMP]
- positive regulation of monocyte chemotactic protein-1 production [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of bone mineralization [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion.
TGF-β1 induces epithelial-mesenchymal transition (EMT) to stimulate cancer cell progression, and TWIST1 is a critical regulator of EMT. In the present study, we determined the underlying mechanisms of TGF-β1-induced TWIST1 expression and its effect on prostate cancer cell invasion. TGF-β1 stimulated STAT3 phosphorylation and HIF-1α expression. Silencing either STAT3 or HIF-1α efficiently attenuated TGF-β1-induced TWIST1 expression. Further ectopic expression of ... [more]
Cancer Lett. Aug. 09, 2013; 336(1);167-73 [Pubmed: 23623921]
Throughput
- Low Throughput
Additional Notes
- ChIP
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STAT3 TWIST1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 1416025 |
Curated By
- BioGRID