BAIT
KCNJ2
ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3
potassium inwardly-rectifying channel, subfamily J, member 2
GO Process (16)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cardiac muscle cell action potential involved in contraction [IMP]
- cellular potassium ion homeostasis [TAS]
- membrane depolarization during cardiac muscle cell action potential [TAS]
- membrane repolarization during action potential [IMP]
- membrane repolarization during cardiac muscle cell action potential [IMP, TAS]
- potassium ion import [IDA]
- potassium ion transmembrane transport [IDA]
- potassium ion transport [IDA]
- protein homotetramerization [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of membrane repolarization [IDA]
- regulation of resting membrane potential [TAS]
- regulation of skeletal muscle contraction via regulation of action potential [IMP]
- relaxation of cardiac muscle [IMP]
- relaxation of skeletal muscle [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HMGB1
HMG1, HMG3, SBP-1, RP11-550P23.1
high mobility group box 1
GO Process (22)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- DNA ligation involved in DNA repair [ISS]
- DNA recombination [ISS]
- DNA topological change [ISS]
- V(D)J recombination [IDA]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- base-excision repair, DNA ligation [IDA]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- chromatin remodeling [IBA]
- dendritic cell chemotaxis [ISS]
- inflammatory response to antigenic stimulus [IEP]
- innate immune response [TAS]
- myeloid dendritic cell activation [ISS]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neuron projection development [ISS]
- positive chemotaxis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding, bending [IMP, ISS]
- RAGE receptor binding [ISS]
- chemoattractant activity [ISS]
- chromatin binding [IBA]
- cytokine activity [ISS]
- damaged DNA binding [ISS]
- double-stranded DNA binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [ISS]
- transcription factor binding [IPI]
- DNA binding, bending [IMP, ISS]
- RAGE receptor binding [ISS]
- chemoattractant activity [ISS]
- chromatin binding [IBA]
- cytokine activity [ISS]
- damaged DNA binding [ISS]
- double-stranded DNA binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [ISS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling.
Potassium ion channels are emerging as promalignant factors involved in cancer progression. In this study, we found that invading human gastric cancer cells express high levels of inwardly rectifying potassium channel 2.1 (Kir2.1). Silencing Kir2.1 markedly reduced the invasive and metastatic capabilities as well as the epithelial-mesenchymal transition (EMT) of gastric cancer cells. The promalignant nature of Kir2.1 in gastric ... [more]
Cancer Res. Jun. 01, 2018; 78(11);3041-3053 [Pubmed: 29549164]
Throughput
- High Throughput
Curated By
- BioGRID