KCNJ2
Gene Ontology Biological Process
- cardiac muscle cell action potential involved in contraction [IMP]
- cellular potassium ion homeostasis [TAS]
- membrane depolarization during cardiac muscle cell action potential [TAS]
- membrane repolarization during action potential [IMP]
- membrane repolarization during cardiac muscle cell action potential [IMP, TAS]
- potassium ion import [IDA]
- potassium ion transmembrane transport [IDA]
- potassium ion transport [IDA]
- protein homotetramerization [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of membrane repolarization [IDA]
- regulation of resting membrane potential [TAS]
- regulation of skeletal muscle contraction via regulation of action potential [IMP]
- relaxation of cardiac muscle [IMP]
- relaxation of skeletal muscle [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STK38
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling.
Potassium ion channels are emerging as promalignant factors involved in cancer progression. In this study, we found that invading human gastric cancer cells express high levels of inwardly rectifying potassium channel 2.1 (Kir2.1). Silencing Kir2.1 markedly reduced the invasive and metastatic capabilities as well as the epithelial-mesenchymal transition (EMT) of gastric cancer cells. The promalignant nature of Kir2.1 in gastric ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNJ2 STK38 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID