FGF23
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of bone mineralization [IDA]
- negative regulation of hormone secretion [ISS]
- negative regulation of osteoblast differentiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphate ion homeostasis [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of vitamin D 24-hydroxylase activity [IDA]
- regulation of phosphate transport [IDA]
- vitamin D catabolic process [IDA]
Gene Ontology Cellular Component
KL
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- aging [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of bone mineralization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia.
Fibroblast growth factor-23 (FGF-23) interacts with a binary receptor complex composed of α-Klotho (α-KL) and FGF receptors (FGFRs) to regulate phosphate and vitamin D metabolism in the kidney. Excess FGF-23 production, which causes hypophosphatemia, is genetically inherited or occurs with chronic kidney disease. Among other symptoms, hypophosphatemia causes vitamin D deficiency and the bone-softening disorder rickets. Current therapeutics that target ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID