BAIT
CREB1
2310001E10Rik, 3526402H21Rik, AV083133, Creb, Creb-1
cAMP responsive element binding protein 1
GO Process (33)
GO Function (15)
GO Component (7)
Gene Ontology Biological Process
- Type I pneumocyte differentiation [IMP]
- axonogenesis [IMP]
- cellular response to growth factor stimulus [IDA]
- cellular response to zinc ion [IDA]
- circadian rhythm [IDA]
- lactation [IMP]
- lung epithelium development [IMP]
- lung saccule development [IMP]
- mammary gland development [IMP]
- memory [IMP]
- negative regulation of transcription by competitive promoter binding [ISO]
- pituitary gland development [IMP]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [ISO]
- positive regulation of fat cell differentiation [IGI]
- positive regulation of hormone secretion [IMP]
- positive regulation of lipid biosynthetic process [IGI]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IGI]
- positive regulation of transforming growth factor beta3 production [ISO]
- protein phosphorylation [ISO]
- protein stabilization [IMP]
- regulation of apoptotic process [ISO]
- regulation of cell size [IGI]
- regulation of circadian rhythm [ISO]
- regulation of transcription, DNA-templated [IDA]
- response to drug [IDA]
- response to glucagon [IMP]
- response to organic substance [ISO]
- secretory granule organization [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- cAMP response element binding [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- cAMP response element binding [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
RHEB
Rheb1
Ras homolog enriched in brain
GO Process (3)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
Mechanistic target of rapamycin (mTOR) integrates multiple extracellular and intracellular signals to regulate cell growth and survival. Hyperactivation of mTOR has been observed in various cancers. Regulation of mTOR activity is thus of importance in physiological processes and tumor development. Here, we present pyruvate dehydrogenase kinase 4 (PDK4) as a novel regulator of mTORC1 signaling. mTORC1 activity was augmented with ... [more]
J. Biol. Chem. Oct. 24, 2014; 289(43);29739-49 [Pubmed: 25164809]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID