OPRM1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- acute inflammatory response to antigenic stimulus [IEP]
- adenylate cyclase-activating dopamine receptor signaling pathway [ISO]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IDA, ISO]
- adenylate cyclase-inhibiting opioid receptor signaling pathway [IDA]
- behavioral response to ethanol [ISO]
- calcium ion transmembrane transport [IMP]
- cellular response to morphine [IDA, IMP]
- immune response [TAS]
- locomotory behavior [ISO]
- negative regulation of Wnt protein secretion [ISO, ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of cAMP-mediated signaling [ISO, ISS]
- negative regulation of cytosolic calcium ion concentration [ISO, ISS]
- negative regulation of nitric oxide biosynthetic process [ISO, ISS]
- neuropeptide signaling pathway [IBA, ISO]
- opioid receptor signaling pathway [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of appetite [IMP]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of neurogenesis [ISO, ISS]
- positive regulation of nitric oxide biosynthetic process [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of excitatory postsynaptic membrane potential [IDA]
- regulation of sensory perception of pain [IDA]
- response to cocaine [IEP]
- response to ethanol [IDA]
- response to food [IEP]
- response to growth factor [IEP]
- response to lipopolysaccharide [IEP]
- response to morphine [IEP]
- sensory perception of pain [ISO, ISS]
- wound healing [IEP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IBA, ISO, ISS]
- G-protein beta-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, IMP]
- beta-endorphin receptor activity [IBA, ISO]
- filamin binding [IMP]
- morphine receptor activity [IDA, IMP]
- neuropeptide binding [IBA]
- opioid receptor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- voltage-gated calcium channel activity [IMP]
- G-protein alpha-subunit binding [IBA, ISO, ISS]
- G-protein beta-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, IMP]
- beta-endorphin receptor activity [IBA, ISO]
- filamin binding [IMP]
- morphine receptor activity [IDA, IMP]
- neuropeptide binding [IBA]
- opioid receptor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- voltage-gated calcium channel activity [IMP]
Gene Ontology Cellular Component
TNIP1
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [IDA]
- glycoprotein biosynthetic process [ISO]
- leukocyte cell-cell adhesion [ISO]
- modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA, ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ABIN-1 Negatively Regulates μ-Opioid Receptor Function.
The μ-opioid receptor (MOR) is a Gi/o protein-coupled receptor that mediates analgesic, euphoric, and reward effects. Using a bacterial two-hybrid screen, we reported that the carboxyl tail of the rat MOR associates with A20-binding inhibitor of nuclear factor κB (ABIN-1). This interaction was confirmed by direct protein-protein binding and coimmunoprecipitation of MOR and ABIN-1 proteins in cell lysates. Saturation binding ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OPRM1 TNIP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID