FMN2
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- cellular response to hypoxia [IMP]
- establishment of meiotic spindle localization [ISS]
- formin-nucleated actin cable assembly [ISS]
- homologous chromosome movement towards spindle pole involved in homologous chromosome segregation [ISS]
- intracellular transport [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein catabolic process [IMP]
- oogenesis [ISS]
- polar body extrusion after meiotic divisions [ISS]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FMN2
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- cellular response to hypoxia [IMP]
- establishment of meiotic spindle localization [ISS]
- formin-nucleated actin cable assembly [ISS]
- homologous chromosome movement towards spindle pole involved in homologous chromosome segregation [ISS]
- intracellular transport [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein catabolic process [IMP]
- oogenesis [ISS]
- polar body extrusion after meiotic divisions [ISS]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.
Although neural progenitor proliferation along the ventricular zone is regulated by β-catenin through Wnt signaling, the cytoskeletal mechanisms that regulate expression and localization of these proteins are not well understood. Our prior studies have shown that loss of the actin-binding Filamin A (FlnA) and actin-nucleating protein Formin 2 (Fmn2) impairs endocytosis of low-density-lipoprotein-receptor-related protein 6 (Lrp6), thereby disrupting β-catenin activation, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID