BAIT
FMN2
RP11-90L13.1
formin 2
GO Process (11)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- cellular response to hypoxia [IMP]
- establishment of meiotic spindle localization [ISS]
- formin-nucleated actin cable assembly [ISS]
- homologous chromosome movement towards spindle pole involved in homologous chromosome segregation [ISS]
- intracellular transport [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein catabolic process [IMP]
- oogenesis [ISS]
- polar body extrusion after meiotic divisions [ISS]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FMN2
RP11-90L13.1
formin 2
GO Process (11)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- cellular response to hypoxia [IMP]
- establishment of meiotic spindle localization [ISS]
- formin-nucleated actin cable assembly [ISS]
- homologous chromosome movement towards spindle pole involved in homologous chromosome segregation [ISS]
- intracellular transport [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein catabolic process [IMP]
- oogenesis [ISS]
- polar body extrusion after meiotic divisions [ISS]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.
Although neural progenitor proliferation along the ventricular zone is regulated by β-catenin through Wnt signaling, the cytoskeletal mechanisms that regulate expression and localization of these proteins are not well understood. Our prior studies have shown that loss of the actin-binding Filamin A (FlnA) and actin-nucleating protein Formin 2 (Fmn2) impairs endocytosis of low-density-lipoprotein-receptor-related protein 6 (Lrp6), thereby disrupting β-catenin activation, ... [more]
Cereb. Cortex Apr. 05, 2018; (); [Pubmed: 29659741]
Throughput
- Low Throughput
Curated By
- BioGRID