BAIT
DDR2
MIG20a, NTRKR3, TKT, TYRO10, RP11-572K18.1
discoidin domain receptor tyrosine kinase 2
GO Process (17)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- biomineral tissue development [ISS]
- chondrocyte proliferation [ISS, TAS]
- collagen fibril organization [ISS]
- collagen-activated tyrosine kinase receptor signaling pathway [IDA]
- endochondral bone growth [ISS]
- extracellular matrix organization [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of extracellular matrix disassembly [ISS]
- positive regulation of fibroblast migration [ISS, TAS]
- positive regulation of fibroblast proliferation [ISS]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- protein autophosphorylation [IDA]
- regulation of bone mineralization [IMP]
- regulation of extracellular matrix disassembly [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TK1
TK2
thymidine kinase 1, soluble
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- deoxyribonucleoside monophosphate biosynthetic process [TAS]
- nucleobase-containing compound metabolic process [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleotide biosynthetic process [EXP]
- protein homotetramerization [IPI]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside salvage [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic screening using an effective strategy for cloning and sequencing paired single guide RNA (sgRNA) libraries and a robust statistical scoring ... [more]
Nat. Biotechnol. Mar. 20, 2017; 0(); [Pubmed: 28319085]
Quantitative Score
- -3.783 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:K562 (EFO:0002067)
- Experimental Setup:Timecourse
- GIST: A-phenotypic negative genetic interaction
- Library:Drug Target-CDKO CRISPRn library
- Significance Threshold: q-value<0.05
Curated By
- BioGRID