BAIT
AOC1
ABP, ABP1, DAO, DAO1, KAO
amine oxidase, copper containing 1
GO Process (9)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- cellular response to azide [IDA]
- cellular response to copper ion [IDA]
- cellular response to copper ion starvation [IDA]
- cellular response to heparin [TAS]
- cellular response to histamine [IDA]
- oxidation-reduction process [IDA]
- response to antibiotic [IDA]
- response to drug [IDA]
- sodium ion transmembrane transport [TAS]
Gene Ontology Molecular Function- calcium ion binding [IDA]
- cation channel activity [IDA]
- copper ion binding [IDA]
- diamine oxidase activity [IDA]
- drug binding [IDA]
- heparin binding [IDA]
- primary amine oxidase activity [IDA]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- quinone binding [IDA]
- receptor activity [IDA]
- sodium channel activity [TAS]
- zinc ion binding [IDA]
- calcium ion binding [IDA]
- cation channel activity [IDA]
- copper ion binding [IDA]
- diamine oxidase activity [IDA]
- drug binding [IDA]
- heparin binding [IDA]
- primary amine oxidase activity [IDA]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- quinone binding [IDA]
- receptor activity [IDA]
- sodium channel activity [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
CSK
c-src tyrosine kinase
GO Process (18)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- adherens junction organization [IBA]
- blood coagulation [TAS]
- cell differentiation [IBA]
- cell migration [IBA]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [TAS]
- innate immune response [IBA]
- morphogenesis of an epithelium [IBA]
- negative regulation of Golgi to plasma membrane protein transport [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- platelet activation [TAS]
- protein phosphorylation [TAS]
- regulation of Fc receptor mediated stimulatory signaling pathway [IBA]
- regulation of cell proliferation [IBA]
- regulation of cytokine production [IBA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic screening using an effective strategy for cloning and sequencing paired single guide RNA (sgRNA) libraries and a robust statistical scoring ... [more]
Nat. Biotechnol. Mar. 20, 2017; 0(); [Pubmed: 28319085]
Quantitative Score
- -3.049 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:K562 (EFO:0002067)
- Experimental Setup:Timecourse
- GIST: A-phenotypic negative genetic interaction
- Library:Drug Target-CDKO CRISPRn library
- Significance Threshold: q-value<0.05
Curated By
- BioGRID