BAIT
CSF1R
C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
colony stimulating factor 1 receptor
GO Process (31)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [IMP]
- cell-cell junction maintenance [IMP]
- cellular response to cytokine stimulus [ISS]
- cellular response to macrophage colony-stimulating factor stimulus [IMP]
- cytokine-mediated signaling pathway [IMP]
- hemopoiesis [IMP]
- inflammatory response [TAS]
- macrophage differentiation [TAS]
- mammary gland duct morphogenesis [TAS]
- monocyte differentiation [TAS]
- multicellular organismal development [TAS]
- osteoclast differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol metabolic process [ISS]
- phosphatidylinositol-mediated signaling [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell motility [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of chemokine secretion [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein serine/threonine kinase activity [ISS]
- positive regulation of protein tyrosine kinase activity [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton reorganization [ISS]
- regulation of bone resorption [ISS]
- regulation of cell shape [IMP]
- ruffle organization [ISS]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LARS2
LEURS, PRLTS4
leucyl-tRNA synthetase 2, mitochondrial
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic screening using an effective strategy for cloning and sequencing paired single guide RNA (sgRNA) libraries and a robust statistical scoring ... [more]
Nat. Biotechnol. Mar. 20, 2017; 0(); [Pubmed: 28319085]
Quantitative Score
- 2.847 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:K562 (EFO:0002067)
- Experimental Setup:Timecourse
- GIST: A-phenotypic positive genetic interaction
- Library:Drug Target-CDKO CRISPRn library
- Significance Threshold: q-value<0.05
Curated By
- BioGRID