BAIT
EPHA2
ARCC2, CTPA, CTPP1, CTRCT6, ECK
EPH receptor A2
GO Process (23)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- activation of Rac GTPase activity [IMP]
- bone remodeling [ISS]
- branching involved in mammary gland duct morphogenesis [ISS]
- cell chemotaxis [IMP]
- cell migration [IMP]
- ephrin receptor signaling pathway [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- keratinocyte differentiation [IMP]
- lens fiber cell morphogenesis [ISS]
- mammary gland epithelial cell proliferation [ISS]
- multicellular organismal development [TAS]
- negative regulation of protein kinase B signaling [IDA]
- osteoblast differentiation [ISS]
- osteoclast differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- protein kinase B signaling [IDA]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of angiogenesis [ISS]
- regulation of blood vessel endothelial cell migration [ISS]
- regulation of cell adhesion mediated by integrin [IDA]
- regulation of lamellipodium assembly [IMP]
- response to growth factor [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HCK
JTK9, p59Hck, p61Hck, RP5-836N17.3
HCK proto-oncogene, Src family tyrosine kinase
GO Process (30)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cell adhesion [TAS]
- cell differentiation [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA, TAS]
- innate immune response-activating signal transduction [TAS]
- integrin-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte degranulation [TAS]
- leukocyte migration involved in immune response [TAS]
- lipopolysaccharide-mediated signaling pathway [TAS]
- mesoderm development [TAS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of actin cytoskeleton reorganization [IDA, IMP]
- positive regulation of actin filament polymerization [TAS]
- positive regulation of cell proliferation [IMP]
- protein autophosphorylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell shape [IMP]
- regulation of defense response to virus by virus [TAS]
- regulation of inflammatory response [TAS]
- regulation of phagocytosis [IMP]
- regulation of podosome assembly [IDA]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- respiratory burst after phagocytosis [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic screening using an effective strategy for cloning and sequencing paired single guide RNA (sgRNA) libraries and a robust statistical scoring ... [more]
Nat. Biotechnol. Mar. 20, 2017; 0(); [Pubmed: 28319085]
Quantitative Score
- 2.86 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:K562 (EFO:0002067)
- Experimental Setup:Timecourse
- GIST: A-phenotypic positive genetic interaction
- Library:Drug Target-CDKO CRISPRn library
- Significance Threshold: q-value<0.05
Curated By
- BioGRID