BAIT
CKM
CKMM, M-CK
creatine kinase, muscle
GO Process (3)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Homo sapiens
PREY
TAOK2
MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2, UNQ2971/PRO7431
TAO kinase 2
GO Process (14)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [IMP]
- actin cytoskeleton organization [IDA]
- activation of MAPKK activity [IDA]
- apoptotic process [NAS]
- cell migration [NAS]
- cellular response to DNA damage stimulus [IDA]
- focal adhesion assembly [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein targeting to membrane [NAS]
- regulation of cell growth [NAS]
- regulation of cell shape [IDA]
- response to stress [IDA]
- stress-activated MAPK cascade [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficiency of combinatorial genetic screening using an effective strategy for cloning and sequencing paired single guide RNA (sgRNA) libraries and a robust statistical scoring ... [more]
Nat. Biotechnol. Mar. 20, 2017; 0(); [Pubmed: 28319085]
Quantitative Score
- 2.905 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:K562 (EFO:0002067)
- Experimental Setup:Timecourse
- GIST: A-phenotypic positive genetic interaction
- Library:Drug Target-CDKO CRISPRn library
- Significance Threshold: q-value<0.05
Curated By
- BioGRID