BAIT
ZFP36L2
BRF2, ERF-2, ERF2, RNF162C, TIS11D
ZFP36 ring finger protein-like 2
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cell proliferation [TAS]
- definitive hemopoiesis [ISS]
- hemopoiesis [ISS]
- mRNA catabolic process [ISS]
- negative regulation of stem cell differentiation [ISS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- regulation of transcription, DNA-templated [TAS]
- somatic stem cell division [ISS]
- somatic stem cell maintenance [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
C3
AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
complement component 3
GO Process (15)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- complement activation [IMP, TAS]
- complement activation, alternative pathway [TAS]
- immune response [TAS]
- innate immune response [TAS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of apoptotic cell clearance [IMP]
- positive regulation of glucose transport [IDA]
- positive regulation of lipid storage [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of complement activation [TAS]
- regulation of immune response [TAS]
- regulation of triglyceride biosynthetic process [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest.
ZFP36L2 promotes the destruction of AU-rich element-containing transcripts, while its regulation and functional significance in cell cycle control are scarcely identified. We show that ZFP36L2 is a cell cycle-regulated CCCH protein, the abundance of which is regulated post-translationally at the respective stages of the cell cycle. Indeed, ZFP36L2 protein was eliminated after release from M phase, and ZYG11B-based E3 ligase ... [more]
Biol Open Mar. 12, 2018; 7(3); [Pubmed: 29449217]
Throughput
- High Throughput
Curated By
- BioGRID