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BAIT

LRRC4B

Lrig4, NGL-3

leucine rich repeat containing 4B

GO Process (1)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

positive regulation of synapse assembly [ISO]

Gene Ontology Molecular Function

receptor binding [ISO]

Gene Ontology Cellular Component

cerebellar mossy fiber [ISO]

RGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Rattus norvegicus

PREY

PTPRF

LARFN5C

protein tyrosine phosphatase, receptor type, F

GO Process (18)

GO Function (7)

GO Component (9)

Gene Ontology Biological Process

cell migration [ISO, ISS]

homophilic cell adhesion via plasma membrane adhesion molecules [IDA]

negative regulation of cell projection organization [IMP]

negative regulation of cell proliferation [IMP]

negative regulation of cytokine-mediated signaling pathway [IMP]

negative regulation of epidermal growth factor receptor signaling pathway [IMP]

negative regulation of insulin receptor signaling pathway [IMP]

negative regulation of neurotrophin TRK receptor signaling pathway [IMP]

negative regulation of receptor binding [ISO, ISS]

nervous system development [IDA]

peptidyl-tyrosine dephosphorylation [IDA, ISO, ISS]

positive regulation of apoptotic process [IDA]

positive regulation of dendrite morphogenesis [IMP]

positive regulation of neuron apoptotic process [IMP]

protein dephosphorylation [IDA]

regulation of axon regeneration [ISO]

regulation of neuron projection development [ISO]

regulation of synapse structure or activity [IMP]

Gene Ontology Molecular Function

chondroitin sulfate proteoglycan binding [ISO]
insulin receptor binding [IDA]
phosphate ion binding [IDA]
protein complex binding [ISO]
protein tyrosine phosphatase activity [IDA, ISO, ISS]
receptor tyrosine kinase binding [IPI]
transmembrane receptor protein tyrosine phosphatase activity [IDA]

Gene Ontology Cellular Component

excitatory synapse [IDA]

extracellular vesicular exosome [ISO]

growth cone [IDA]

intracellular membrane-bounded organelle [IDA]

neuron projection [IDA, ISO]

neuronal cell body [IDA, ISO]

plasma membrane [IDA]

RGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Rattus norvegicus

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses.

Woo J, Kwon SK, Choi S, Kim S, Lee JR, Dunah AW, Sheng M, Kim E

Synaptic adhesion molecules regulate multiple steps of synapse formation and maturation. The great diversity of neuronal synapses predicts the presence of a large number of adhesion molecules that control synapse formation through trans-synaptic and heterophilic adhesion. We identified a previously unknown trans-synaptic interaction between netrin-G ligand-3 (NGL-3), a postsynaptic density (PSD) 95-interacting postsynaptic adhesion molecule, and leukocyte common antigen-related (LAR), ... [more]

Nat. Neurosci. Apr. 01, 2009; 12(4);428-37 [Pubmed: 19252495]

Throughput

Low Throughput

Curated By

BioGRID