BAIT
LEPR
LEPROT, Leprb, Modb1, OB-RGRP, Obr, db, diabetes, obese-like, obl, RP23-31K16.2
leptin receptor
GO Process (10)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- angiogenesis [ISO]
- cholesterol metabolic process [IGI]
- eating behavior [ISO]
- leptin-mediated signaling pathway [ISO]
- negative regulation of gluconeogenesis [IMP]
- negative regulation of hydrolase activity [IGI]
- positive regulation of MAPK cascade [ISO]
- regulation of metabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PLCG1
NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, RP3-511B24.2
phospholipase C, gamma 1
GO Process (23)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell receptor signaling pathway [TAS]
- activation of MAPKK activity [TAS]
- activation of phospholipase C activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium-mediated signaling [IMP]
- cell migration [IMP]
- cellular response to epidermal growth factor stimulus [IDA, IMP]
- cytokine-mediated signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [IMP, TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate metabolic process [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [IMP]
- signal transduction [NAS, TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways.
Leptin is an adipokine that regulates food intake and energy expenditure by activating its hypothalamic leptin receptor (LR). Members of the insulin receptor substrate (IRS) family serve as adaptor proteins in the signaling pathways of several cytokines and hormones and a role for IRS2 in central leptin physiology is well established. Using mammalian protein-protein interaction trap (MAPPIT), a cytokine receptor-based ... [more]
Mol. Endocrinol. Apr. 01, 2008; 22(4);965-77 [Pubmed: 18165436]
Throughput
- Low Throughput
Additional Notes
- MAPPIT Experiment
Curated By
- BioGRID