PTPRS
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NME2
Gene Ontology Biological Process
- cell adhesion [TAS]
- integrin-mediated signaling pathway [IDA]
- negative regulation of apoptotic process [IMP]
- nucleobase-containing small molecule interconversion [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleoside triphosphate biosynthetic process [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of keratinocyte differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of epidermis development [IMP]
- regulation of transcription, DNA-templated [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NME2 associates with PTPσ to transduce signals from chondroitin sulfate proteoglycans.
Chondroitin sulfate proteoglycans (CSPGs) are a major component of glial scars, inhibiting axonal growth in the central nervous system. Protein tyrosine phosphatase, receptor type S (PTPσ) has been identified as a receptor for CSPGs, whereas its downstream signaling pathway remains to be fully understood. Here, we report that nucleoside diphosphate kinase 2 (NME2) interacts with PTPσ. We screened proteins associated ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID