BAIT

MYCN

MODED, N-myc, NMYC, ODED, bHLHe37
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
Alzheimer's Disease Project
GO Process (1)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

RAB5C

L1880, RAB5CL, RAB5L, RABL
RAB5C, member RAS oncogene family
Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation.

Murphy DM, Buckley PG, Bryan K, Das S, Alcock L, Foley NH, Prenter S, Bray I, Watters KM, Higgins D, Stallings RL

Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths. The single most important prognostic indicator of poor clinical outcome in this disease is genomic amplification of MYCN, a member of a family of oncogenic transcription factors.We applied MYCN chromatin immunoprecipitation to microarrays (ChIP-chip) using MYCN amplified/non-amplified cell lines ... [more]

PLoS ONE Dec. 04, 2009; 4(12);e8154 [Pubmed: 19997598]

Throughput

  • High Throughput

Additional Notes

  • ChIP

Curated By

  • BioGRID